Male’s Ticking Bio Clock

Did old men mating with young women cause Dwarfism, Schizophrenia, Neurofibromatosis and skull/facial deformities in the human genome?


According to a new study on old fathers and their offspring; looks like it.  Men 40 years and older have a 1 in 47 chance of fathering a Schizophrenic child compared to a father 25 or younger who only has a chance of 1 in 141.  Men 50 and older have a 50% chance of fathering a Down Syndrome child.  Dwarfism has the same percentages.  And the genetic mutations don’t just stop with old fathers.  Their offspring (even if young while creating the new generation) have a higher percentage of passing on the mutated genes.  Scientist believe the reason old sperm have such damaging effects on the genetic code is due to how many times the spermatogonia (immature stem cells in the testes) have divided and replicated by the time a man reaches age 50.  Unlike women who are born with their eggs already formed, men produce sperm as they grow.  Each year after puberty the sperm stem cells have 23 replications a year.  By the time a man reaches his 50’s his sperm stem cells have gone through more than 800 rounds of replications and division.  Each R&D has an increase risk of mutating.  The mutations cause the problems.  As well as bad mutations, the older sperm lose their strength and ability to swim straight.  This  makes it more difficult for an older man to impregnate a woman. (Which is probably natures way of keeping the bad sperm from creating too much damage.)  So the next time you hear about “female biological clock ticking” remember “a man’s clock ticks just as loudly!”

 

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